How it works The Science Learn FAQ See Your Cost HSA/FSA For Research

Quit nicotine with a
physician-reviewed plan.

For cigarettes, vapes, pouches, dip, or chew. A licensed physician reviews your case and prescribes evidence-based cessation medication when clinically appropriate.

Step 1 of 5
What do you currently use?
We ask so your physician understands your full nicotine use.
Independent physician review required. Submitting does not guarantee a prescription.
See how it works
44%
Abstinent in weeks 9–12†
2.5×
More likely than placebo
Fast
Physician review
HSA/FSA
Eligible expense
† Phase III varenicline smoking-cessation trial (Gonzales 2006). Outcomes vary by individual situation and physician recommendation.
How it works

Three steps.
Twelve weeks.
A completely new chapter.

Step 01
Tell us about yourself

A 5-minute intake covering your nicotine history, medical background, and goals. Cigarettes, vaping, pouches — all welcome. Completely private. No phone call required.

About 5 minutes
Step 02
A physician reviews your case

A licensed physician reviews your intake within 24 hours. If treatment is clinically appropriate, the physician issues a prescription based on their independent medical judgment. No video call required.

Typically within 24 hours
Step 03
If prescribed, medication arrives at your door

If prescribed, your medication ships directly to your door. Your physician sets your protocol — typically a 12-week course, with an optional extension where clinically appropriate. Individual results vary.

Delivery included · estimated 3–5 days
"Because of its high level of effectiveness, varenicline is an important life-saving medication."
National Centre for Smoking Cessation and Training · UK NHS
The Science

The science of medication-assisted cessation.

Nicotine dependence is hard to break with willpower alone. Roughly 95% of unassisted quit attempts fail within a year. The reason is biological, not personal — nicotine rewires the brain's dopamine system, and breaking that loop without pharmacological support is a fight against your own neurochemistry. Medication-assisted cessation, when matched to the patient, dramatically improves outcomes. Among FDA-approved cessation medications, varenicline has the strongest pooled evidence as a single-medication therapy.

Varenicline breaks the loop at its source — binding to the same receptors nicotine targets, delivering just enough signal to quiet cravings, while blocking nicotine from delivering its usual reward. Over 12 weeks, your brain relearns what normal feels like. No nicotine required.

You may know varenicline as Chantix. In 2021, Pfizer recalled brand-name Chantix after a manufacturing impurity was found above the FDA's acceptable daily intake limit. The FDA stated there was no immediate risk to patients and that the benefits of stopping smoking outweighed the theoretical long-term risk from the impurity. FDA-approved generic varenicline is now available — and far more affordable than the brand ever was. Most people don't know it's available again. Respiro was built to expand access to this treatment for the millions of people who want to quit but have never been able to get there.

12-week abstinence rates · Published clinical trials
Varenicline 44%
Bupropion ~30%
Placebo 17–18%
Source: Gonzales et al., JAMA 2006 · Phase III cigarette-smoking cessation trial · Varenicline vs. bupropion SR vs. placebo · Weeks 9–12 continuous abstinence. Individual results may vary.
44%
Abstinent in weeks 9–12
Phase III varenicline smoking-cessation trial (Gonzales 2006). Placebo arm: 17–18%. Outcomes vary by individual situation.
2.5×
More likely than placebo
Same Phase III trial. Same data. Placebo: 17–18%. Gonzales et al., JAMA 2006.
FDA
Approved, generic, and available
Available since 2006. WHO Essential Medicines list since 2021.
12wk
Standard treatment protocol
Optional extended protocol available for patients who benefit from additional support.
Respiro uses evidence-based prescription cessation protocols. Individual results vary.
Coming soon Beta

You won't be doing this alone.

Coach Rio, the Respiro SMS quit coach — illustrated portrait
Meet Coach Rio.

An SMS quit companion in development. Once live, Coach Rio will send medication reminders on the schedule you choose, celebrate milestones with the actual money you've saved, and help you through cravings as they hit.

Currently in beta. Availability and features may change before public launch — or may not ship at all. Your prescription and physician care are not affected by Coach Rio availability.

  • ✓ Medication reminders on your schedule — once, twice, or as often as you need. You pick the cadence.
  • ✓ Milestone celebrations at Day 7, 14, 30, 90, 180, and one year — with your real dollars saved
  • ✓ Craving SOS — text CRAVING and Coach Rio talks you through it
  • ✓ Refill alerts 5 days before your supply runs out, so you never lapse

Beta · coming soon. Opt-in only when launched. Reply STOP anytime.

Coach Rio · beta preview. The messages below are illustrative previews of the planned product. Coach Rio is not yet live. When launched, opt-in will be required and standard message/data rates may apply.
Sample messages · preview only
Morning, Kyle. Time for your AM dose — full glass of water, full meal. Your stomach will thank us. 💊
Evening dose check-in. Take it with dinner if you haven't already. 💊
Day 30. Thirty days nicotine-free. You've saved $210. Your body is already recovering. Screenshot this — you earned it. 🎉
CRAVING
I've got you. Grab a glass of cold water and step outside if you can. Breathe in for 4, out for 6. Cravings peak in about 4 minutes and then they fade. You're stronger than this one. Don't break the streak.
The numbers

30 million people
want out. Most never find a way.

70%

Of current nicotine users say they want to quit. Most have tried and failed — not because they lack willpower, but because they were never given the right tool.

CDC · 2024
Behavioral Risk Factor Surveillance
3–5%

Cold turkey success rate at one year. It's the method most people default to — and the one with the worst odds. The failure isn't personal. The approach is just wrong.

Published clinical data
vs 44% with FDA-approved cessation pharmacotherapy in clinical trials
<10%

Of people who want to quit are ever prescribed evidence-based cessation pharmacotherapy. The awareness and access gap is real.

CDC MMWR · Babb et al. 2017
Quitting Smoking Among Adults — United States, 2000–2015
30 seconds · free
How much money have you burned on nicotine?
Most people have never actually done the math.
See what your habit is actually costing.
Show me my number →
Not ready to quit yet?

Cut back first.
Reach zero in 12 weeks.

Many smokers aren't ready to commit to a quit date today. The FDA-approved varenicline label includes a gradual reduction protocol for exactly this scenario — begin treatment, reduce usage by 50% every four weeks, reach abstinence by week 12. Your physician decides whether this approach is appropriate for your specific situation.

Weeks 1–4
Start · reduce 50%

Begin treatment. Cut daily nicotine use in half. No quit date pressure.

Weeks 5–8
Reduce 50% again

Cut daily nicotine use in half a second time. Continue working with your physician on your reduction plan.

Weeks 9–12
Reach zero

Continue reducing toward complete abstinence. Your physician may recommend continuing varenicline for 12 more weeks.

Week 13+
Stay there

If you've reached abstinence by week 12, your physician may recommend continuing treatment for another 12 weeks to support long-term cessation, per FDA label.

From the FDA-approved label

"For patients who are sure that they are not able or willing to quit abruptly, consider a gradual approach … reduce smoking by 50% from baseline within the first four weeks, by an additional 50% in the next four weeks, and continue reducing with the goal of reaching complete abstinence by 12 weeks."

Varenicline label · Section 2.1 (DailyMed) →
Start your intake  →

Tell the physician you'd prefer a gradual reduction protocol. They review your case and decide whether it's clinically appropriate.

Simple pricing

No surprises.
No hidden fees.

Step 1 · One time
$75
Consultation fee · includes physician review
  • ✓ Licensed physician review within 24hrs
  • ✓ Personalized quit protocol
  • ✓ Prescription issued only if clinically appropriate
  • ✓ Ongoing physician messaging access
  • ✓ HSA/FSA eligible expense
Satisfaction guarantee: if our physician recommends against prescription treatment and you'd prefer not to explore alternatives, we'll refund the consultation in full.
Monthly Treatment
Step 2 · Ongoing
$150
Per month · cancel anytime · no commitment
  • ✓ Medication shipped to your door — nothing to pick up
  • ✓ Automatic refills so you never miss a dose
  • ✓ Ongoing physician access throughout your 12–24 week protocol
  • ✓ Side effect support when you need it
  • ✓ Cancel anytime — no fees, no friction
  • ✓ HSA/FSA eligible expense
Medication is only charged if prescribed and shipped. You're never charged for medication you don't receive.

A routine in-office physician visit typically costs $150–300 without insurance — before you fill the prescription. Respiro includes the consultation, medication, and delivery in one monthly price.

Medication only dispensed if prescribed by your independent clinician. Pricing reflects evaluation and program access.

Our promise
Our satisfaction guarantee.

Some patients have medical histories that make a particular medication a poor fit. If our physician reviews your case and recommends against treatment — and you'd prefer not to explore alternatives — we'll refund the $75 consultation in full. We'd rather your physician tell you honestly than prescribe something that isn't right for you.

Why We Built This

We watched people quit twenty times and still lose.

Patches. Gum. Willpower. The same loop, over and over. Most people who try to quit are never offered evidence-based prescription cessation care — even though it dramatically improves the odds. The medications exist. The trials are decades old. The access is the problem. That made us angry in a way we still haven't fully resolved.

Cessation pharmacotherapy has been studied for decades. Among FDA-approved single-medication options, varenicline has produced the strongest results: in a Phase III cigarette-smoking trial, the quit rate was about 44% in weeks 9–12, compared with 17–18% on placebo (Gonzales et al., JAMA 2006). The evidence has been in the literature for twenty years. Yet less than 10% of people who want to quit are ever prescribed it.

The gap isn't information. It's access. Getting a prescription meant scheduling an appointment, sitting in a waiting room, explaining yourself to someone with twelve minutes for you. Most people never made it through that friction. We decided the friction was the problem. So we removed it.

— Kyle, Founder

All clinical decisions are made by independent licensed physicians. Respiro coordinates access to care and does not practice medicine.

i Important Safety Information

Varenicline is a prescription medication and is not right for everyone. Common side effects can include nausea, abnormal dreams, sleep changes, headache, constipation, and other stomach symptoms. Less common but serious risks include mood or behavior changes, depression, suicidal thoughts, seizures, allergic reactions, serious skin reactions, and cardiovascular events.

Tell your physician about your medical history, current medications, pregnancy or breastfeeding status, kidney problems, seizure history, mental health history, and any prior reaction to varenicline. Use only as directed.

Full prescribing information (DailyMed)
Ready when you are

Your nicotine-free
life starts here.

Planned 50-state launch. Takes 60 seconds.

Not a medical evaluation and not a prescription. No commitment. Just your spot in line.
Prescriptions are only issued if clinically appropriate after independent physician review.